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RECORD NUMBER: 294 OF 4520

OLS Field Name OLS Field Data
Main Title Assessment of toxicity of automotive metallic emissions. volume I, Assessment of fuel additives emission toxicity via selected assays of nucleic acid and protein synthesis /
Author Holbrook, David J.
CORP Author North Carolina Univ., Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1976
Report Number EPA/600/1-76/010A; EPA-68-02-1205
Stock Number PB-251 231
Subjects Automobiles--Motors--Exhaust gas--Environmental aspects. ; Lead--Toxicology.
Additional Subjects Palladium inorganic compounds ; Toxicity ; Fuel additives ; Manganese inorganic compounds ; Lead inorganic compounds ; Platinum inorganic compounds ; Ribonucleic acids ; Nucleic acids ; Metals ; Toxicology ; Exhaust gases ; Emission ; Experimental data ; Rats ; Laboratory animals ; Bioassay ; Lethal dosage ; Dose rates ; In vitro analysis ; Metabolism ; Drugs ; In vivo analysis ; Toxic hazards ; Environmental health ; Automobile exhausts ; Catalytic reactors(Exhaust systems)
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NTIS  PB-251 231 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation vi, 61 pages : illustrations ; 28 cm.
Abstract Lead salts are an emission product from mobile (or automotive) emission sources due to the addition of tetraethyl lead to gasoline. Because of known toxic properties of lead salts, it has been proposed that alkyl manganese compounds be substituted as a fuel additive for tetraethyl lead. With the introduction of platinum and palladium in the catalytic converters of 1975-model year vehicles, it is of concern to determine the quantities of platinum and palladium metal and salts which will be in emission products and the biological effects of these compounds on mammalian tissues. Various parameters of toxicity have been studied for salts of manganese, lead, palladium, and platinum. Acute toxicities (LD-50 doses) are reported for both intraperitoneal injection and oral administration. Concentrations of metallic ions following dietary administration are reported, as are effects on weights of five organs (liver, kidney, spleen, heart, testes). Also following dietary administration, hepatic microsomes were isolated and the following parameters related to in vitro drug metabolism were measured, yield of microsomal protein/g liver, in vitro activities of aniline hydroxylase and aminopyrine demethylase, content of cytochromes P-450 and b5/mg microsomal protein. Development of a rapid and convenient method for the analysis of ribosomal RNA in studies of RNA synthesis is reported.
Notes "January 1976." Contract No. 68-02-1205. Microfiche.
Place Published Research Triangle Park, NC :
Supplementary Notes See also Volume 2, PB-251 232.
Corporate Au Added Ent Health Effects Research Laboratory (Research Triangle Park, N.C.). ; United States. Environmental Protection Agency. Office of Research and Development.
Title Ser Add Ent Research reporting series Environmental health effects research ;
PUB Date Free Form 1976.
Series Title Untraced Environmental health effects research series ; EPA-600/1-76-010A
Ti Tra Differently Assessment of fuel additives emission toxicity via selected assays of nucleic acid and protein synthesis
NTIS Prices PC A04/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20031003130238
Language eng
Origin NTIS
Type MERGE
OCLC Rec Leader 01520nam 2200313Ka 45020