Main Title |
Excretion of Cadmium and Mercury in Rat Saliva. |
Author |
Smith, Ladd W. ;
Borzelleca, Joseph F. ;
|
CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1980 |
Report Number |
EPA-R-804318; EPA-600/J-80-335; |
Stock Number |
PB82-124785 |
Additional Subjects |
Saliva ;
Excretion ;
Cadmium ;
Mercury(Metal) ;
Metals ;
Blood pressure ;
Rats ;
Laboratory animals ;
Reprints ;
|
Internet Access |
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-124785 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The excretion of cadium and mercury in saliva was studied in urethane-anesthetized male rats given single intravenous injections of 109CdCl2 or 203HgCl2 (0.1 or 1.0 mg divalent cation/kg). Pilocarpine (20 mg/kg, ip) was used to stimulate salivation. All doses produced a distinct and persistent increase in blood pressure (15-25 mm Hg), an increase in salivary flow rate and an increase (19-26%) in salivary gland weight. Metal levels in saliva (S) and submaxillary gland tissue (T), relative to blood (B), plasma (P), and filtrate (F) were determined. Cadmium and mercury were detected in S and T at both doses. The following relative order was apparent: S/F > S/P approx. S/B. S/F ratios were > 1, suggesting a concentrating effect by the salivary gland. S/B and S/P ratios for mercury increased with increasing dose; S/B and S/P ratios for cadmium decreased with increasing dose. Similar dose-related effects were apparent in the T/B and T/P ratios. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 54(1), p134-140 1980. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Excretion of Cadmium and Mercury in Rat Saliva. |
PUB Date Free Form |
c1980 |
Category Codes |
6T; 6P; 57Y; 57S |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323807369 |
Origin |
NTIS |
Type |
CAT |