| Main Title |
Determination of the Acute Oral Toxzicity of Dipropylene Glycol in Rats with Cover Letter dated 03/28/94. (Sanitized). |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
8EHQ-86940000276S |
| Stock Number |
OTS0572379 |
| Additional Subjects |
Toxicology ;
Health effects ;
Dipropylene glycol ;
Toxicity ;
Acute toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
CAS No 110-98-5 ;
Toxic substances ;
Laboratory animals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572379 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
The test material was Al 1 sample of the test substance was received from the principal on January 22, 1980. It was a clear colourless liquid, designated: dipropylene glycol. Test animals : Young adult albino rats (Wistar-derived) from the Institute's colony were used, The body weights of males varied from 182 to 283g, those of females from 110 to 164 g. The rats were housed in groups of five in screen- bottomed stainless steel cages in a well-ventilated room, maintained at 23 + or - 1 deg C. Before dosing the rats were fasted overnight. Experimental design : After some preliminary observations the test material was given by gavage to groups of five males and five females in single doses of 8,6, 10,4, 12,4, 14,9 or 17,9 ml per kg body weight. After treatment the rats received stock diet and tap water ad libitan. They were observed for signs of intoxication during a 14-day period, after which autopsies were carried out on the survivors. The LDSO was calculated according to the method of Neil (Biometrics 8 (1952) 249-263). Results: Within a few hours after dosing, the rats showed sedation and signs of ataxia. Later on coma was frequently observed. Deaths occurred between 6 hours and three days after treatment. Then the survivors recovered gradually and looked quite healthy at the end of the observation period. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Mar 1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A01/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501290 |
| Origin |
NTIS |
| Type |
CAT |
