| Main Title |
Propylene Dichloride: Dominant Lethal Study in Sprague-dawley Rats (Final) with Cover Letters. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1989 |
| Report Number |
40-8967206 |
| Stock Number |
OTS0527736 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
2-dichloropropane ;
Genotoxicity ;
Chromosomal Effects ;
Mammals ;
Rats ;
Oral ;
Toxic substances ;
Laboratory animals ;
CAS No 78-87-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0527736 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
113p |
| Abstract |
Propylene dichloride was evaluated for mutagenicity in groups of 30 male Sprague-Dawley rats fed concentrations of 0, 0.024, 0.10%, or 0.24% in the diet for 14 weeks, then mated to pairs of untreated adult females each week for 2 weeks. Female rats were killed 14 days after the middle of the breeding period for evaluation of dominant lethal effects by measurement of resorption rate. High-concentration males had decreased water consumption and mid- and high- concentration males had decreased body weight. The treatment had no adverse effects on male fertility as determined by mating performance or resorption rate. The treatmentdid not induce a dominant lethal effect, indicating that the test compound was not mutagenic to male germ cells in rats under the conditions of this assay. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1989 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802900 |
| Origin |
NTIS |
| Type |
CAT |
