Main Title |
Teratology Studies in Rats & Rabbits with Oleylamine and Range-finidng Teratology Studies in Rats & Rabbits with Oleylamine (Final Reports) with Cover Letter Dated 11/28/1989. |
CORP Author |
Springborn Labs., Inc., Wareham, MA.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
2000 |
Report Number |
40-8984324 |
Stock Number |
OTS0525408 |
Additional Subjects |
Toxicology ;
Health effects ;
Oleylamine ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Oral ;
Gavage ;
Rats ;
Toxic substances ;
Laboratory animals ;
CAS No 112-90-3
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0525408 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
845p |
Abstract |
Oleylamine was evaluated for potential teratogenicity to mated female rats (28/group) administered oral doses of 0, 10, 40, or 80 mg/kg/day by gavage in corn oil on gestation days 6 through 15. Doses were selected by means of a range-finding study. No treatment-related mortalities occurred. Clinical signs were observed in the 40 (salivation) and 80 mg/kg/day (salivation and rales) groups, along with dose-dependent body weight losses, reduced weight gain, and decreased food consumption at these levels. No evidence of embryotoxicity, fetotoxicity, or teratogenicity was noted. A developmental study was conducted in rabbits (22 inseminated females/group) orally administered 0, 3, 10, or 30 mg/kg/day by gavage in corn oil on gestation days 6 through 18. Doses were determined in a range-finding study. Dose- related maternal toxicity (2 deaths in high-dose group, 1 female from each treatment group aborted prior to scheduled sacrifice, rales, irritation of mouth area, decreased body weight, weight gain, and food consumption) was noted at 10 mg/kg/day and above. No signs of embryotoxicity, fetotoxicity or teratogenicity were noted. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
2000 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A99/MF A99 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028802640 |
Origin |
NTIS |
Type |
CAT |