| Main Title |
Propylene Oxide: Assessment of Neurotoxic Potential in Male Rats - with Cover Letter dated 10/24/1985. |
| CORP Author |
Dow Chemical U.S.A., Midland, MI. Mammalian and Environmental Toxicology Research Lab.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
40-8554111 |
| Stock Number |
OTS0510835 |
| Additional Subjects |
Toxicology ;
Health effects ;
Propylene Oxide ;
Neurotoxicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 75-56-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510835 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
125p |
| Abstract |
Propylene oxide was evaluated for neurotoxicity in 30 male Fischer 344 rats (F0 generation from a two-generation reproduction study) receiving whole body exposure to nominal concentrations of 0, 30, 100, or 300 ppm 6 hours/day, 5 days/week, for approximately 24 weeks. Observational battery tests were performed at approximately 8, 16, and 24 weeks of exposure. Also preformed prior to sacrifice were hindlimb grip strength test and an open-field activity test. After sacrifice an extensive histopathologic examination of the central and peripheral nervous system was conducted. There were no differences in the pre-sacrifice test results between the treated and control groups. Mild neuroaxonal dystrophy (eosinophilic spheroids) in the region of the nucleus gracilis was present in the majority of control and treated animals; the incidence and severity of the condition was more prevalent in the controls than tin he high dose animals. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801630 |
| Origin |
NTIS |
| Type |
CAT |
