| Main Title |
Inhalation Teratology Study in Rabbits with Nitrobenzene (Final Report). |
| CORP Author |
Bio-Dynamics Research and Development Corp., Eugene, OR.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8424492 |
| Stock Number |
OTS0510651 |
| Additional Subjects |
Toxicology ;
Health effects ;
Nitrobenzene ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 98-95-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510651 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
370p |
| Abstract |
The embryotoxicity and teratogenicity of nitrobenzene were evaluated in mated female New Zealand White rabbits (22/group) exposed by inhalation to nitrobenzene at nominal concentrations of 0, 10, 40 or 100 ppm for 6 hrs/day during gestation days (GD) 7-19. The animals were sacrificed on the day evidence was observed that they aborted or delivered prematurely or on GD 30, whichever occurred sooner. Significant differences between treated and control animals were observed in the following: increased absolute and relative liver weight and methemoglobin values (mid- and high-dose groups). No significant differences between treated and control animals were observed in the following: mortality, pregnancy, abortion or premature delivery rates, body weights, corpora lutea and uterine implantation data, fetal weight, crown-rump distance, fetal sex distribution, and external, visceral and skeletal evaluation of fetuses. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A17/MF A17 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801600 |
| Origin |
NTIS |
| Type |
CAT |
