| Main Title |
In Vivo Bone Marrow Chromosome Study in Rats with Acetone Cyanohydrin (Final Report) with Cover Letter dated 04/25/1986. |
| CORP Author |
Center for Human Development, Jackson, MS.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
878216400 |
| Stock Number |
OTS0510328 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acetone Cyanohydrin (75-86-5) ;
Genotoxicity ;
Chromosomal Effects ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 75-86-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510328 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
79p |
| Abstract |
The ability of acetone cyanohydrin to cause chromosome aberrations was evaluated in bone marrow cells of Sprague-Dawley CD rats (24/sex/group) receiving a single administration of test material at 0, 1.5, 5 or 15mg/kg by oral gavage. Sacrifice was at 6, 12, 24 and 48 hours after administration of test material. No statistically significant increases (KW-ANOVA) in the frequency of chromosome aberrations were observed at any dose level regardless of sacrifice time compared to the controls. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Monsanto Chemical Co., Dayton, OH. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801460 |
| Origin |
NTIS |
| Type |
CAT |
