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OLS Field Name OLS Field Data
Main Title Lung Injury Caused by Ambient Levels of Ozone.
Author Huang, Y. ; Chang, L. Y. ; Miller, F. J. ; Crapo., J. D. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher 1988
Year Published 1988
Report Number EPA-R-813113; EPA/600/J-88/554;
Stock Number PB91-117606
Additional Subjects Ozone ; Lung ; Injuries ; Rats ; Exposure ; Epithelium ; Reprints ; Air pollution effects(Animals) ; Lung volume measurements ; Pulmonary alveoli ; Macrophages
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NTIS  PB91-117606 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/04/1991
Collation 8p
Abstract Exposures to low levels of O3 cause epithelial and interstitial injury in the proximal alveolar region. The sequential development of this lesion caused by a simulated ambient pattern of O3 was studied by exposing Fisher 344 rats to 0.06ppm O3 overnight with an 8 hr daytime exposure having a slow increase to a peak of 0.25 ppm and then gradually decreasing back to 0.06 ppm. Animals were studied using EM morphometric techniques after 7, 21 and 90 days exposure as well as post 90 days exposures. The early changes in O3 exposed animals included increases of volumes in type II epithelium (60%), type I epithelium (16%), cellular interstitium (52%), non-cell interstitium (33%), and in alveolar macrophages (180%). The response showed a biphasic reaction with the early injury subsiding after 21 days of O3 exposure. The animals exposed for 90 days showed a 28% increase in relative volume of type I and a 42% increase in type II epithelia.
Supplementary Notes Pub. in Jnl. of Aerosol Medicine, v1 n3 p180-183 Jul 88. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: Lung Injury Caused by Ambient Levels of Ozone.
Category Codes 68A; 57E; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 101124276
Origin NTIS
Type CAT