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Main Title Report of the State-of-the-Science Workshop: Evaluation of Epidemiological Data Consistency for Application in Regulatory Risk Assessment.
CORP Author Johns Hopkins Univ., Baltimore, MD. Bloomberg School of Public Health.; Environmental Protection Agency, Washington, DC.
Year Published 2011
Stock Number PB2013-102539
Additional Subjects Epidemiological data ; Assessment ; Chemicals ; Pollutants ; Regulatory limits ; Health standards ; Health risk
Library Call Number Additional Info Location Last
NTIS  PB2013-102539 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 07/24/2013
Collation 23p
Abstract Epidemiological data have often had a key role in the assessment of risks associated with exposure to chemicals and pollutants and for development of regulatory limits in the environment and in occupational settings. Examples include the development of occupational health standards and health risk values in the United States for benzene (OSHA 1987; U.S. EPA 2003), as well as for the U.S. National Ambient Air Quality Standards for Particulate Matter (U.S. EPA 2006). The strengths and weaknesses, as well as the overall value of the use of epidemiological data in regulatory risk assessment have been widely discussed in the scientific and public health policy literature. Epidemiological data have been criticized as too often flawed by quality issues and incompletely controlled sources of bias (see, for example, Graham et al. 1995). Epidemiological studies of environmental agents involving typical ambient levels of exposure have been particularly characterized as uninformative or especially susceptible to bias and uncontrolled confounding because the target for estimation is often relatively small risk ratios that are dismissed as 'weak associations' (Gamble and Lewis 1996). Proponents of use of epidemiological data, while acknowledging the limitations of observational studies, advance its strengths; the investigation of the effects of real exposures as received by the general population, the characterization of an effect across the full range of susceptibility in the population and, most significantly, the direct relevance of epidemiologic evidence to public health (Whittemore 1986; Gordis 1988; Hertz-Picciotto 1995; Burke 1995; Samet, Schnatter, and Gibb 1998). In addition, the ability to ascertain relatively low relative risks has improved with advances in exposure assessment and study design methodologies.
Supplementary Notes Sponsored by Environmental Protection Agency, Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA.
PUB Date Free Form 30 Jun 2011
Category Codes 57E; 57U
NTIS Prices PC A03
Document Type NT
Cataloging Source NTIS/MT
Control Number 111302340
Origin NTIS
Type CAT