||Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex.
Crofton, K. M. ;
Reiter, L. W. ;
Mailman, R. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Hazardous materials ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Radioligand binding displacement studies were conducted to determine the effects of Type I and II pyrethroids on (3H)-flunitrazepam (FLU), (3H)-muscimol (MUS), and (35S)t-butylbicyclophosphorothionate (TBPS) binding. Competition experiments with (3H)-FLU and (3H)-MUS indicate a lack of competition for binding by the pyrethroids. Type I pyrethroids failed to compete for the binding of (35S)-TBPS at concentrations as high as 50 pM. Type II pyrethroids inhibited (35S)-TBPS binding to rat brain synaptosomes with Ki values ranging from 5-10 pM. The data presented here suggest that the interaction of Type II pyrethroids with the GABA receptor-ionophore complex is restricted to a site near the TBPS/picrotoxinin binding site.
||Pub. in Toxicology Letters, v35 p183-190 1987. Prepared in cooperation with North Carolina Univ. at Chapel Hill.
|NTIS Title Notes
||Reprint: Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex.
|PUB Date Free Form
||57Y; 68E; 68G
||PC A02/MF A01