Main Title |
U-Shaped Dose-Response Curves: Their Occurrence and Implications for Risk Assessment. |
Author |
Davis, J. M. ;
Svendsgaard., D. J. ;
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/171; |
Stock Number |
PB91-115808 |
Additional Subjects |
Epidemiology ;
Toxicology ;
Lead(Metal) ;
Nervous system disorders ;
Children ;
Blood ;
Reprints ;
Dose response relationships ;
Risk assessment
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-115808 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
A class of curvilinear dose-response relationships in toxicological and epidemiological studies may be roughly described by 'U-shaped' curves. Such curves reflect an apparent reversal or inversion in the effect of an otherwise toxic agent at a low or intermediate region of the dose continuum. Several examples of U-shaped dose response functions are presented to illustrate the variety of agents and end points that can follow this form. Such findings are not thought to represent a unitary phenomenon, but may be explained through numerous possible principles or mechanisms, some of which are illustrated and discussed in general terms. U-shaped dose-response curves raise important issues for toxicological and environmental health risk assessments, particularly in the identification of no-observed-effect levels and in the evaluation of multiple outcomes and trade-offs between potential risks and benefits of a given agent. It is especially important to avoid focusing exclusively on an apparent improvement in one end point and failing to consider other, possibly deleterious effects of the same agent. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v30 p71-83 1990. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: U-Shaped Dose-Response Curves: Their Occurrence and Implications for Risk Assessment. |
Category Codes |
68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/23 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
036522842 |
Origin |
NTIS |
Type |
CAT |