Main Title |
Effects of Inorganic Lead In vitro on Ion Exchanges and Respiratory Metabolism of Rat Kidney Cortex. |
Author |
van Rossum, G. D. V. ;
Kapoor, S. C. ;
Rabinowitz, M. S. ;
|
CORP Author |
Temple Univ., Philadelphia, PA. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA-68-03-2381; EPA/600/J-85/154; |
Stock Number |
PB86-101003 |
Additional Subjects |
Lead(Metal) ;
Ion exchangers ;
In vitro analysis ;
Rats ;
Kidneys ;
Tissues ;
Metabolism ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-101003 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The effects of Pb2+ added in vitro to tissue slices, isolated tubules and isolated mitochondria of rat kidney cortex have been studied. Slices were depleted of K+ and loaded with Na+, Cl- and water by pre-incubation at 1C, and reversal of these changes was then induced by incubation under metabolically favorable conditions. The net reaccumulation of K+ was reduced by a maximum of 30% when Pb2+ was present in the medium, the maximal effect being caused by 200 micromoles Pb2+. Lead also caused a reduction of Na+ extrusion which was approximately equimolar with its effect on K+, but it did not affect the extrusion of Cl- and water. The initial rates of the net, active movements of K+ and Na+ were not altered by Pb2+, divergence from control values only being noted after 15-30 min incubation. |
Availability Notes |
Pub. in Archives of Toxicology 56, p175-181 1985. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Inorganic Lead In vitro on Ion Exchanges and Respiratory Metabolism of Rat Kidney Cortex. |
PUB Date Free Form |
c1985 |
Category Codes |
6T; 6A; 57Y; 57B |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
533917510 |
Origin |
NTIS |
Type |
CAT |