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RECORD NUMBER: 36 OF 250

OLS Field Name OLS Field Data
Main Title Chronic toxicity of lead and cadmium : I. changes in the central nervous system of the parental generation of rats after chronic intoxication with lead and cadmium /
Other Authors
Author Title of a Work
Herman, Zbigniew S.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1980
Report Number EPA-600/1-80-012
Stock Number PB81-110850
OCLC Number 07562712
Subjects Cadmium--Toxicology. ; Lead--Toxicology. ; Cadmium--Health aspects. ; Lead--Health aspects. ; Cadmium Poisoning. ; Lead Poisoning.
Additional Subjects Toxicology ; Lead(Metal) ; Cadmium ; Bioassay ; Rats ; Exposure ; Central nervous system ; Dosage ; Laboratory animals ; Experimental data ; Blood chemical analysis ; Liver ; Kidney ; Concentration(Composition) ; Trace elements ; Toxic substances ; Urinalysis ; Hyperkinesis ; Biogenic amines
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=91013YNI.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/1-80-012 Region 3 Library/Philadelphia, PA 10/11/1996
EJBD ARCHIVE EPA 600-1-80-012 Headquarters Library/Washington,DC 01/30/2012
EJBD  EPA 600-1-80-012 Headquarters Library/Washington,DC 04/23/2014
EKAM  EPA 600/1-80-012 Region 4 Library/Atlanta,GA 12/03/1999
EKBD  EPA-600/1-80-012 Research Triangle Park Library/RTP, NC 06/30/2000
ELBD  EPA 600-1-80-012 AWBERC Library/Cincinnati,OH 11/14/2003
NTIS  PB81-110850 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation iii, 16 p. ; 28 cm.
Abstract This paper examines the effects of chronic exposure to trace amounts of lead and cadmium on the central nervous system of male Westar rats. Treatments consisted of two levels of lead (5 or 50 ppm), two levels of cadmium (0.1 or 5 ppm), and two combined dosages (5 ppm lead and 0.1 ppm cadmium, or 50 ppm lead and 5 ppm cadmium). Treatments were administered in buffered drinking water. The lower dosages generally produced hyperactivity, while higher dosages produced hypoactivity. Effects of lead and cadmium on biogenic amines varied with dose and area of the brain. Biochemical analysis of blood and urine showed no changes in the hematocrit or hemoglobin, but the activity of Delta-ALA dehydratase and serum phosphatase were differentially affected. Concentrations of lead and cadmium in the liver and kidney increased, and positive interaction effects were noted. The results suggest that the level of biogenic amines in discrete brain areas is a very sensitive indicator of central nervous system toxicity to lead and/or cadmium.
Notes "EPA-600/1-80-012". "Performing Organization: Departments of Pharmacology, Biochemistry, Cytology and Histology, Central Animal Farm of Silesian Medical Academy in Katowice, Poland"--Technical Report Data. "January 1980." "Slaska Akademia Medyczna, Katowice, Poland"--Cover. Includes bibliographical references (p. 14-16).
Place Published Research Triangle Park, N.C.
Access Notes Also available via the World Wide Web.
Corporate Au Added Ent Health Effects Research Laboratory (Research Triangle Park, N.C.)
Title Ser Add Ent Research reporting series.; Environmental health effects research series.; EPA-600/1-80-012.
PUB Date Free Form 1980
Series Title Traced Research reporting series Environmental health effects research series EPA-600/1-80-012
Series Title Untraced Research reporting series\ Environmental health effects research series\ EPA-600/1-80-012
NTIS Prices PC A02/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20120125131606
Language eng
Origin OCLC
Type MERGE
OCLC Rec Leader 01688cam 2200373Ia 45020