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RECORD NUMBER: 4312 OF 4452

Main Title Triethyltin-Induced Neuronal Damage in Neonatally Expose Rats.
Author Veronesi, B. ; Bondy, S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/126;
Stock Number PB86-243227
Additional Subjects Toxicology ; Bioassay ; Exposure ; Rats ; Laboratory animals ; Neurons ; Reprints ; Neurotoxicology ; Triethyltin/alkyl metal
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NTIS  PB86-243227 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Abstract Neuropathological and biochemical effects of neonatal exposure to the alkyl metal triethyltin were examined in Long Evans juvenile male rats. Rats were injected intraperitoneally on post-natal day 5 with 6 mk/kg of triethyltin bromide and sampled on day 20. The brains of tin-treated animals weighed significantly less than either saline or starved controls and exhibited a marked anterior-posterior atrophy. Histologically, neuronal necrosis was noted in the enthorhinal and transitional cortex, an observation confirmed by immunocytochemical staining of astrocytes. Hippocampal involvement was further evidenced by a protrusion of the molecular layer of the dentate gyrus, and an abnormal staining pattern of acetylcholinesterase in this layer. Sections stained by the Timm's method for the deposition of heavy metals showed a marked reduction in the staining of the hippocampal CA4-2 sectors and an absence of stained laminae in the outer molecular layer of the dentate gyrus. Receptor binding assays indicated a selective depression of the benzodiazepine receptor in the hippocampus of tin-treated pups compared to starved controls. Taken in concert, these data indicate that neonatal exposure to triethyltin produces severe neuronal damage in the posterior cortex and a derangement of hippocampal afferent circuitry.
Supplementary Notes Pub. in Neurotoxicology, v7 n1 p69-80 Apr 86. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Triethyltin-Induced Neuronal Damage in Neonatally Expose Rats.
PUB Date Free Form 1986
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 632416767
Origin NTIS
Type CAT