Main Title |
Toxicological Investigationof Maleic Anhydride, Lot No. QB1151 with Cover Letter. |
CORP Author |
Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1984 |
Report Number |
878214766 |
Stock Number |
OTS-0206655 |
Additional Subjects |
Health effects ;
Toxicity ;
Laboratory animals ;
Acute ;
Lethal doses ;
Signs and symptoms ;
Dose levels ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Maleic anhydride ;
CAS No 108-31-6
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0206655 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
1288p |
Abstract |
In an acute toxicity study, male and female Sprague-Dawley rats (2 males and 3 females/group, except highest-dose level group which had 4 males and 1 female) were given single gavage exposures to maleic anhydride (as a 10% solution/suspension in corn oil). Dose levels of 316, 398, 501, and 631 mg/kg resulted in the deaths of 0, 1, 3, and 4 animals, respectively (duration of observation period was not reported although the survival time was reported to be one to four days). The LD50 is 495 (410 to 580) mg/kg. Toxic symptoms observed included loss of appetite, diarrhea, and increasing weakness. Gross pathology observed at autopsy included renal and liver congestion, and inflammation of the gastric mucosa. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
5 Nov 1984 |
Category Codes |
57Y |
NTIS Prices |
PC A99/MF A99 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019001840 |
Origin |
NTIS |
Type |
CAT |