Main Title |
Trimethyltin Disrupts Acoustic Startle Responding in Adult Rats. |
Author |
Ruppert, P. H. ;
Dean, K. F. ;
Reiter, L. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/115; |
Stock Number |
PB85-110005 |
Additional Subjects |
Acoustics ;
Toxicology ;
Behavior ;
Rats ;
Laboratory animals ;
Reprints ;
Trimethyltin ;
TMT
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-110005 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Trimethyltin (TMT) is a limbic-system toxicant which also produces sensory dysfunction in adult animals. In the present experiment, the authors examined the effects of TMT on the acoustic startle response. Adult male, Long-Evans rats (N=12/dose) received a single i.p. injection of either 0, 4.0, 5.0 or 6.0 mg/kg TMT hydroxide as the base. The number of responses, latency and peak amplitude of the startle response to a 13 kHz, 120 dB tone were measured 2 h, 2 weeks, and 4 weeks after dosing. For each test session, 10 stimuli were presented at each of three background noise levels (50, 65 and 80 dB). By 2 h after dosing, the number of response and response amplitude were decreased following 4.0-6.0 mg/kg TMT; these treatment effects persisted through 4 weeks after dosing. Increases in latency were also seen following all dosages of TMT. These data suggest that TMT produces disruption of function within the acoustic-startle pathway. |
Supplementary Notes |
Pub. in Toxicology Letters 22, p33-38 1984. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Trimethyltin Disrupts Acoustic Startle Responding in Adult Rats. |
PUB Date Free Form |
1984 |
Category Codes |
6T; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
501824617 |
Origin |
NTIS |
Type |
CAT |