||Studies on the Percutaneous Absorption of Parathion and Paraoxon. II. Distribution of 32P-Labelled Parathion within the Skin.
Fredriksson., Torsten ;
||Communicable Disease Center, Atlanta, Ga.
||PB-280 573; PB-280 565
Phosphorus organic compounds ;
Labeled substances ;
Experimental data ;
Laboratory animals ;
Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester) ;
Toxic substances ;
Pesticide residues ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The distribution of 32P-labelled parathion (E605, or diethyl 4-nitrophenyl thiononophosphate) within the skin following topical application for various periods of time was studied in excised skin from man, rat, rabbit, and cat. Two different approaches were chosen: (1a) determination of radioactivity in 25 consecutive cellulose tape strips from the surface of human skin, (1b) autoradiography of the same strips; and (2) autoradiography of skin sections with the use of four different techniques. Various factors influencing the autoradiograms were studied, special attention being paid to artefacts due to diffusion, type of radiation, and exposure time of the photosensitive material. It was found that parathion penetrates into hair follicles and sebaceous glands to some extent, but it was concluded that this is not necessarily the main route of absorption. There also was increasing activity below the epidermal layers, and transepidermal absorption is as likely. The results were discussed with special attention to the interpretation of the autoradiograms and to the implications for other studies of the percutaneous absorption of parathion.
||Included in PB-280 565, Journal articles on toxicology. Group 12.
||Pub. in Acta Dermato-Venereologica, v41 p344-352 1961.
||Included in the report, Journal Articles on Toxicology, Group 12, PB-280 565.
||Journal articles on toxicology. Group 12.
||Reprint: Studies on the Percutaneous Absorption of Parathion and Paraoxon. II. Distribution of 32P-Labelled Parathion within the Skin,
|PUB Date Free Form
||6T; 6P; 57Y; 57S; 68E; 68G
||(Order as PB-280 565, MF A01)