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OLS Field Name OLS Field Data
Main Title Experimental Infection of the Respiratory Tract with Mycoplasma Pneumoniae.
Author Hu, Ping-Chuan ; Kirtz, Jerome M. ; Gardner, Donald E. ; Powell, Dwight A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA/600/J-81-028;
Stock Number PB81-233801
Additional Subjects Respiratory system ; Infectious diseases ; Immunity ; Aerosols ; Hamsters ; Laboratory animals ; Labeled substances ; Lung ; Reprints ; Mycoplasma pneumoniae ; Pathogens
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NTIS  PB81-233801 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Abstract Mycoplasma pneumoniae, a common human respiratory pathogen, has been studied experimentally for years using intranasal inoculation of the golden Sytrian hamster. Because of recent evidence outlining the role in pulmonary immune development of particle size and depth of mycoplasma deposition in the hamster lung, the authors developed an aerosol chamber for the reproducible aerosolization of radiolabeled M. pneumoniae. Organisms were labeled to high specific activity by the incorporation of 3H-oleic acid and aerosolized under air-flow and humidity conditions creating a mean particle diameter of 2.0 micrometers. Under these conditions, viable mycoplasmas were reproducibly and evenly distributed to all major lobes of the lung. Examination of radioactive clearance and organism viability within the lung during the first 48 hr after aerosolization have suggested a minimal role for macrophage mycoplasmacidal activity and a more prominent role for ciliary clearance. Data from aerosol infections of hamsters with radio-labeled M. pneumoniae should provide a unique opportunity to examine in a highly controlled manner the effects of air pollutants on the initial stages of infection as well as effects on the development of pulmonary immunity and histologic alterations.
Supplementary Notes Pub. in Environmental Health Perspectives, v35 p101-106 1980.
NTIS Title Notes Journal article.
Title Annotations Reprint: Experimental Infection of the Respiratory Tract with Mycoplasma Pneumoniae.
PUB Date Free Form Jul 81
Category Codes 6E; 57J
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323802319
Origin NTIS
Type CAT