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RECORD NUMBER: 24 OF 108

OLS Field Name OLS Field Data
Main Title Conformational Flexibility of Bleomycin-A2: A Carbon 13 Spin-Lattice Relaxation Time Study.
Author Krishna, N. R. ; Dallas, Jerry L. ; Mooberry, Ed S. ; Sakai, Ted T. ; Allen, Richard C. ;
CORP Author Alabama Univ. in Birmingham.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1978
Report Number EPA-R-804916; EPA-600/J-78-191;
Stock Number PB82-154881
Additional Subjects Spin lattice relaxation ; Isotopic labeling ; Reprints ; Molecular conformation ; Bleomycin ; NSC 125066 ; Carbon 13
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NTIS  PB82-154881 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Abstract The extent of segmental motion of the backbone and sidechain carbons of the glycopeptide antibiotic, bleomycin-A(2) in aqueous solution, has been determined from the natural abundance carbon-13 spin-lattice relaxation times T(1) measured at 67.89 MHz. The backbone carbons of the central residues have an average T(1) of 163 msec, corresponding to an isotropic rotational correlation time of 3.9 x 10 to the -10 power sec. The backbone and sidechain carbons exhibit varying degrees of motional freedom. The solution conformation of bleomycin-A(2) is discussed in terms of the conformational flexibility available to these carbons.
Supplementary Notes Pub. in Biochemical and Biophysical Research Communications, v85 n1 p363-370, 14 Nov 78. Prepared in cooperation with North Carolina Agricultural and Technical State Univ., Greensboro, and Florida State Univ., Tallahassee.
NTIS Title Notes Journal article.
Title Annotations Reprint: Conformational Flexibility of Bleomycin-A2: A Carbon 13 Spin-Lattice Relaxation Time Study.
PUB Date Free Form 29 Sep 78
Category Codes 7D; 99F
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323810603
Origin NTIS
Type CAT