| Main Title |
Initial Submission: TSCA Health and Safety Cover Sheet Reporting Results of Developmental Toxicity Screening in Rats after Oral Administration of LKA-3957, dated 08/18/1999. |
| CORP Author |
Bayer A.G., Dormagen (Germany, F.R.).; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1999 |
| Report Number |
8EHQ-0899-14534 |
| Stock Number |
OTS0559781 |
| Additional Subjects |
Toxicity ;
Oral administration ;
Rats ;
Evaluation ;
Dosage ;
Fetuses ;
Females ;
Tolerance ;
Body weight ;
Necropsies ;
Laboratory animals ;
Mortality ;
Food consumption ;
Gavage ;
Investigations ;
Pregnancy ;
LKA 3957 ;
Carboxymethylcellulose
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0559781 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Four (100, 200 mg/kg) or 3 (1000 mg/kg, two with implantation sites) inseminated Wistar rats were treated daily by gavage with 100, 300 or 1000 mg of LKA 3957/kg body weight/day in 0.5% carboxymethylcellulose in demineralized water from day 6 to day 19 p.c. The fetuses were delivered by cesarean section on day 20 p.c. Investigations were performed on the general tolerance of the test compound by the females as well as on its effects on intrauterine development (pregnancy rate, number of fetuses and resorptions, external findings in the fetuses, fetal weight, and fetal skeletal malformations and variations (wavy ribs only)). Appearance, behavior, mortality and feed consumption for the females in the 100 mg/kg dose group were unaffected. Furthermore, there was no clear effect on body weight development in this dose group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
23 Aug 1999 |
| Category Codes |
57Y; 57O |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500860 |
| Origin |
NTIS |
| Type |
CAT |
