||Action of Pesticides on Conduction in the Rat Superior Cervical Ganglion.
Whitcomb, Ernest R. ;
Santolucito., John A. ;
||Health Effects Research Lab., Research Triangle Park, N.C.
Nerve cells ;
Central nervous system ;
Neuromuscular junctions ;
Oxygen consumption ;
In vitro analysis ;
Laboratory animals ;
Experimental data ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The mechanism of toxic action of the chlorinated hydrocarbon insecticides has not been established. Matsumura (1971) and Wooley and Barron (1968) have suggested that DDT may act on the sodium channels of nerve membranes. These investigators have related the instability of the nerve membrane to the toxic symptoms to the intact animal. Of possible 'model' systems, the superior cervical ganglion was selected. The preganglionic and postganglionic transmission and the O2 consumption of the superior cervical ganglion of the rat were measured in vitro following the onset of symptoms after oral dosing. From these parameters the effect of insecticides on axonal and synaptic transmission was evaluated in defining its action in the intact animal. The materials tested included the chlorinated hydrocarbon pesticides - Chlordane, DDT, Lindane, and Toxaphene; three organophosphorus compounds - DFP, Parathion, and Paraxon; and the alkaloid - Nicotine.
||Pub. in Bulletin of Environmental Contamination and Toxicology, v15 n3 p348-356 1976.
|NTIS Title Notes
||Reprint: The Action of Pesticides on Conduction in the Rat Superior Cervical Ganglion.
|PUB Date Free Form
||Not available NTIS