||Biochemical Effects in the Rabbit of Repeated Administration of a Mixture of DDT, Carbaryl, and Parathion.
Hassan, A. ;
Cueto, Jr., C. ;
||Center for Disease Control, Atlanta, Ga.
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Some biochemical effects of the repeated administration to rabbits of DDT (5 mg/kg), carbaryl (5 mg/kg), and parathion (0.5 mg/kg) were studied during 222 days. No significant changes were found in the blood or urine levels of amino acids. The tubular phosphorus reabsorption remained unaltered. The blood coagulation time was considerably shortened in the treated animals. The urinary excretion of 5-hydroxy-3-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxymandelic acid (VMA) was higher in treated animals as compared to that of controls, indicating an increased rate of metabolism of serotonin and catecholamines, respectively. This increased metabolism is in turn believed to be a consequence of increased biosynthesis and release of biogenic amines caused by a stress mechanism induced by the administered pesticides. The amounts of 5-HIAA and VMA returned to normal 45 days after cessation of treatment.
||Pub. in Zeitschrift fuer Naturforschung, Band 25b Heft 5 p521-525 1970.
||Included in the report, Journal Articles on Toxicology. Group 4, PB-279 272.
||Reprint: Biochemical Effects in the Rabbit of Repeated Administration of a Mixture of DDT, Carbaryl, and Parathion,
|PUB Date Free Form
||6T; 57Y; 68E; 68G
||(Order as PB-279 272, MF A01)