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RECORD NUMBER: 143 OF 1540

OLS Field Name OLS Field Data
Main Title Biochemical Effects in the Rabbit of Repeated Administration of a Mixture of DDT, Carbaryl, and Parathion.
Author Hassan, A. ; Cueto, Jr., C. ;
CORP Author Center for Disease Control, Atlanta, Ga.
Year Published 1970
Stock Number PB-279 277
Additional Subjects Pesticides ; Toxicology ; Insecticides ; DDT ; Rabbits ; Carbamates ; Laboratory animals ; Biochemistry ; Blood ; Hematology ; Metabolism ; Reprints ; Carbaryl ; Parathion ; Toxic substances
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NTIS  PB-279 277 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 5p
Abstract Some biochemical effects of the repeated administration to rabbits of DDT (5 mg/kg), carbaryl (5 mg/kg), and parathion (0.5 mg/kg) were studied during 222 days. No significant changes were found in the blood or urine levels of amino acids. The tubular phosphorus reabsorption remained unaltered. The blood coagulation time was considerably shortened in the treated animals. The urinary excretion of 5-hydroxy-3-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxymandelic acid (VMA) was higher in treated animals as compared to that of controls, indicating an increased rate of metabolism of serotonin and catecholamines, respectively. This increased metabolism is in turn believed to be a consequence of increased biosynthesis and release of biogenic amines caused by a stress mechanism induced by the administered pesticides. The amounts of 5-HIAA and VMA returned to normal 45 days after cessation of treatment.
Supplementary Notes Pub. in Zeitschrift fuer Naturforschung, Band 25b Heft 5 p521-525 1970.
Availability Notes Included in the report, Journal Articles on Toxicology. Group 4, PB-279 272.
Title Annotations Reprint: Biochemical Effects in the Rabbit of Repeated Administration of a Mixture of DDT, Carbaryl, and Parathion,
PUB Date Free Form 1970
Category Codes 6T; 57Y; 68E; 68G
NTIS Prices (Order as PB-279 272, MF A01)
Primary Description 500/01
Document Type NT
Cataloging Source NTIS/MT
Control Number 323738112
Origin NTIS
Type CAT