Main Title |
Assessment of the Male Reproductive System in the Preweaning Rat Following Mn3O4 Exposure. |
Author |
Laskey, J. W. ;
Rehnberg, G. L. ;
Hein, J. F. ;
Laws, S. C. ;
Edens, F. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. Dept. of Poultry Science. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/112; |
Stock Number |
PB85-243996 |
Additional Subjects |
Manganese oxides ;
Reproduction(Biology) ;
Toxicology ;
Oxides ;
Rats ;
Exposure ;
Ingestion(Biology) ;
Reprints ;
Particulates
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-243996 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
Long-Evans rat pups were dosed orally from birth to 21 days with particulate Mn3O4 to obtain a daily dose of 0, 71 or 214 micrograms Mn/g BW/d. Assessment of the hypothalamic, pituitary or testicular functions were determined by measuring the endogenous or stimulated serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (FSH), luteinizing hormone (LH) and/or testosterone (T) at 21 or 28 days of age. Body, testes and seminal vesicles weight and tissue concentrations of Mn treatment effects were seen in body and testes weights. No effects were seen either on unstimulated or stimulated FSH or LH serum concentrations. Although no Mn treatment effects were seen on endogenous or two hour hCG stimulated serum T concentrations, there was a reduction in the serum T following seven days of hCG stimulation. The hypothalamic Mn concentrations in animals with these reproductive effects were three times those where alterations in the dopaminergic pathway have been reported. |
Supplementary Notes |
Prepared in cooperation with North Carolina State Univ. at Raleigh. Dept. of Poultry Science. |
Availability Notes |
Pub. in Jnl. of Toxicology and Environmental Health 15, n2 p339-350 Feb 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Assessment of the Male Reproductive System in the Preweaning Rat Following Mn3O4 Exposure. |
PUB Date Free Form |
c1985 |
Category Codes |
6T; 57Y |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
529826625 |
Origin |
NTIS |
Type |
CAT |