||Biochemical Effects of Repeated Administration of p,p'-DDT on the Squirrel Monkey.
Cranmer, M. ;
Peoples, A. ;
Chadwick., R. ;
||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
||found in PB-280 889
||PB-280 895, found in PB-280 889
Laboratory animals ;
Experimental data ;
Lethal dosage ;
Physiological effects ;
Blood plasma ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||p,p'-DDT was administered po in peanut oil to 5 groups of 6 squirrel monkeys at doses of 50, 5, 0.5, 0.05, and 0 mg/kg/day. Blood samples were taken weekly from each animal; several hematologic parameters were determined, and plasma amylase, aldolase, glutamic-pyruvic transaminase, and isocitric dehydrogenase were measured. Two monkeys from each group were killed after 2, 4, and 6 mo and in vitro liver homogenate enzyme activity was measured using p-nitroanisole and ethyl p-nitrophenyl phenylphosphonothioate as substrates. No discernible effects on hematologic values or plasma enzyme levels were observed. The stimulation of the 2 liver homogenate mixed-function oxidases was maximal after 2 mo treatment. There were no significant differences in the levels of homogenate enzyme activity at the 3 sacrifice periods. The monkeys given 50 mg/kg/day all died within 14 wk of starting treatment; deaths did not occur at the other doses.
||contained in PB-280 889 titled Journal Articles on Toxicology. Group 14.
||Pub. in Toxicology and Applied Pharmacology 21, p98-101 1972.
||Included in the report, Journal Articles on Toxicology, Group 14, PB-280 889.
||Reprint: Biochemical Effects of Repeated Administration of p,p'-DDT on the Squirrel Monkey,
|PUB Date Free Form
||5 Oct 70
||6T; 6A; 57Y; 57B; 68E
||(Order as PB-280 889, MF A01)