Main Title |
Octanol/Water Partition Coefficients and Aqueous Solubilities of Organic Compounds. |
Author |
Wasik, Stanley P. ;
Tewari, Yadu B. ;
Miller, Michele M. ;
Matire, Daniel E. ;
|
CORP Author |
National Bureau of Standards, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1981 |
Report Number |
NBSIR-81-2406; |
Stock Number |
PB82-141797 |
Additional Subjects |
Solubility ;
Organic compounds ;
Water ;
Gas chromatography ;
Partition coefficients ;
Octanols ;
High pressure liquid chromatography ;
Numerical solution
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-141797 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
68p |
Abstract |
A generator column method for measuring the octanol/water partition coefficient, K(o/w) and the aqueous solubility, C sup w sub s, is described. When water is pumped through a generator column packed with solid support coated with an organic stationary phase, an aqueous solution is generated that is in equilibrium with the stationary phase. The solute concentration in the eluted aqueous phase was measured either by high pressure liquid chromatography or by solvent extraction followed by gas chromatographic analysis. Aqueous solubilities and octanol/water partition coefficients of organic solutes, falling into 7 general chemical classes, have been systematically determined using the modified generator column method. From thermodynamics an equation is derived relating K(o/w) to the volume-fraction-based solute activity coefficient in water gamma sup w sub s, the latter being determinable from C sup w sub s. For each class of compounds, excellent linear correlations are found between log K(o/w) and log gamma sup w sub s with slopes close to the theoretical value of unity. |
PUB Date Free Form |
Dec 81 |
Category Codes |
7D; 99F# |
NTIS Prices |
PC A04/MF A01 |
Primary Description |
500/00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323809330 |
Origin |
NTIS |
Type |
CAT |