||Chemical Characterization and Disposition Studies with 1,2,7,8-Tetrabromodibenzofuran in the Rat.
Kedderis, L. B. ;
Jackson, J. A. ;
Patterson, D. G. ;
Grainger, J. ;
Diliberto, J. J. ;
||North Carolina Univ. at Chapel Hill. Curriculum in Toxicology. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;Centers for Disease Control and Prevention, Atlanta, GA. Div. of Environmental Health Lab. Sciences.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Nuclear magnetic resonance ;
High pressure liquid chromatography ;
Mass fragmentography ;
Infrared spectroscopy ;
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||The present studies were designed to characterize the chemical disposition of a tetrabrominated dibenzofuran. The isomer-specific pattern of 1,2,7,8-tetrabromodibenzofuran (TBDF) was chemically characterized using high-pressure liquid chromatography, gas chromatography/mass spectrometry, infrared absorption, and proton nuclear magnetic resonance techniques. The absorption, distribution, and elimination of 1,2,7,8-(4,6-(3)H)-TBDF were examined in the rat following a single oral, dermal, or intravenous dose of 1 nmol/kg. The decline in hepatic concentrations observed in the iv and bile studies occurred in conjunction with metabolic elimination as well as a slight accumulation in adipose tissue. Dermal absorption of 1,2,7,8-TBDF, quantified as the amount contained in tissues (excluding the skin site) and excreta at 72h, was estimated to be 29% of the administered dose. Thus, the general disposition profile of 1,2,7,8-TBDF in the rat is similar to that of other polyhalogenated aromatic hydrocarbons. Due to its rapid elimination, which is consistent with its predicted susceptibility to metabolic elimination, acute exposure to 1,2,7,8-TBDF would not be expected to result in the degree of toxicity associated with other more persistent congeners.
||Pub. in Jnl. of Toxicology and Environmental Health 41, n1 p53-69 Jan 94. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. and Centers for Disease Control and Prevention, Atlanta, GA. Div. of Environmental Health Lab. Sciences. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
||%AUT:L. S. /Birnbaum
|NTIS Title Notes
||Reprint: Chemical Characterization and Disposition Studies with 1,2,7,8-Tetrabromodibenzofuran in the Rat.
||PC A03/MF A01