Main Title |
Acute Oral Toxicity (ld50) Study in Albino Mice Report with Cover Letter Dated 12/19/1977. |
CORP Author |
Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
2000 |
Report Number |
40-7749059 |
Stock Number |
OTS0512867 |
Additional Subjects |
Toxicology ;
Health effects ;
Hexachlorocyclopentadiene ;
Acute Toxicity ;
Mammals ;
Mice ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 77-47-4
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0512867 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
Acute oral toxicity was evaluated in groups of 5 male and 5 female Charles River CD-1 mice administered single doses of hexachlorocyclopentadiene as a solution in corn oil by oral gavage at levels of 21.5, 46.4, 100, 215, 464, 1000 and 2150 mg/kg of body weight. Mortality was observed in 1 female in the 46.4 mg/kg dose group, and all 10 animals in both the 1000 and 2150 mg/kg dose groups. The LD50 value was calculated to be 679 mg/kg (618-747 mg/kg 95% confidence limits) by the moving average method. Clinical observations included diarrhea, hypoactivity, decreased limb tone, ataxia, and ptosis. Gross necropsy findings were notreported. |
Supplementary Notes |
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Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
2000 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801680 |
Origin |
NTIS |
Type |
CAT |