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RECORD NUMBER: 259 OF 1150

OLS Field Name OLS Field Data
Main Title Drinking Water Criteria Document for Simazine.
CORP Author Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Drinking Water.
Publisher May 90
Year Published 1990
Stock Number PB90-215344
Additional Subjects Potable water ; Toxicology ; Water quality ; Herbicides ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Simazine ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Chromosome aberrations
Holdings
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NTIS  PB90-215344 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 85p
Abstract Simazine is the common name for 2-chloro-4,6-bis(ethylamino)-1,3,5 triazine. The acute oral LD50 estimates are 5,000 mg/kg or higher in rats, mice, rabbits, and birds, but a dose of 500 mg/kg has been reported to be lethal in sheep. Pharmacotoxic signs in sheep included incoordination, tremors, weakness, cyanosis, and clonic convulsions. A dose of 4,200 mg/kg caused anorexia, weight loss, and some lethality in rats. In a three-generation reproduction study with Charles River rats fed simazine 80W in the diet at 50 or 100 ppm, a parental toxicity NOAEL of less than 50 ppm and a LOAEL of 50 ppm were identified based on reduced weight gains in males during the premating periods. In a teratology study with rats, simazine administered at high doses (1,250 and 2,500 mg/kg/day) during gestation days 6 through 15 delayed fetal development and was embryotoxic but not teratogenic. Most tests of mutagenic potential for simazine have been negative.
Supplementary Notes Sponsored by Environmental Protection Agency, Washington, DC. Office of Drinking Water.
NTIS Title Notes Draft rept. (Final).
Category Codes 57U; 57Y; 68D
NTIS Prices PC A05/MF A01
Primary Description 700/03
Document Type NT
Cataloging Source NTIS/MT
Control Number 022219788
Origin NTIS
Type CAT