||Toxicity of Paraquat to Rats and Its Effect on Rat Lungs.
Kimbrough, R. D. ;
Gaines., T. B. ;
||Food and Drug Administration, Chamblee, Ga.
||found in PB-280 889
||PB-280 898, found in PB-280 889
Laboratory animals ;
Experimental data ;
Lethal dosage ;
Physiological effects ;
Paraquat herbicide ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Acute and subacute toxicity studies were conducted with paraquat (1,1'-dimethyl-4,4'-dipyridylium dimethylsulfate) in adult Sherman rats. The single-dose oral LD50 was 100 mg.kg in females. The 90-dose oral LD50 in female rats was 21 mg/kg, giving a chronicity factor of 5.2. The acute dermal LD50 was 80 mg/kg in male rats and 90 mg/kg in females. Studies of lung tissue with the electron microscope after a single oral dose indicate that the first discernible changes are pulmonary edema, swelling of the epithelium, an increase in collagen, and an effect on the ribosomes of the membranous pneumocytes. Light microscopic studies of lungs affected by paraquat after po and iv administration or local instillation showed intra-alveolar hemorrhage, edema, extensive fibrosis, and changes in the epithelium. Local instillation of 0.05 mg/kg of paraquat into lung and 0.8 mg/kg into skeletal muscle caused local fibrosis.
||contained in PB-280 889 titled Journal Articles on Toxicology. Group 14.
||Pub. in Toxicology and Applied Pharmacology 17, p679-690 1970.
||Included in the report, Journal Articles on Toxicology, Group 14, PB-280 889.
||Reprint: Toxicity of Paraquat to Rats and Its Effect on Rat Lungs,
|PUB Date Free Form
||10 Nov 69
||6T; 57Y; 68G; 68E
||(Order as PB-280 889, MF A01)