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OLS Field Name OLS Field Data
Main Title Killer Lymphocytes [electronic resource] /
Type EBOOK
Author Berke, Gideon.
Other Authors
Author Title of a Work
Clark, William R.
Publisher Springer Netherlands,
Year Published 2005
Call Number QR180-189.5
ISBN 9781402032707
Subjects Medicine. ; Oncology. ; Immunology. ; Medical virology. ; Hematology. ; Microbiology. ; Bacteriology.
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-1-4020-3270-7
Collation VIII, 362 p. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Basic Immunobiology: A Primer -- Cytotoxic T Lymphocytes: Generation and Cellular Properties -- Cytotoxic T Lymphocytes: Target Cell Recognition and Binding -- Cytotoxic T Lymphocytes: Target Cell Killing: Cellular Parameters -- Cytotoxic T Lymphocytes: Target Cell Killing: Molecular mechanisms -- Innate Cell-mediated Immunity -- The Role of Cytotoxicity in Allograft Rejection In Vivo -- Cytotoxicity in Immune Defenses Against Intracellular Parasites -- Killer Cells and Cancer -- Autoimmunity -- Homeostasis, Memory and CTL Vaccines. The existence of a unique kind of immune cell - the killer lymphocyt- which destroys other cells in a highly specific manner, has fascinated immunologists for almost half a century. How do these cells, whose precursors have lived in communal harmony with their host, decide that some of their cohabitants must die? And how do they kill them? The definition of killer lymphocytes came from discovery of their roles in a wide range of in vivo phenomena such as transplant rejection, virus infection and its related immunopathologies, and anti-tumor responses. Yet for the most part almost everything we know about these cells has come from studying them in vitro. They have yielded their secrets slowly and reluctantly. To understand fully how they work, geneticists and immunologists had to unravel the major histocompatibility systems of vertebrates, a long and torturous road that provided some of the darkest hours of immunology. The search for antigen-sensing receptors on both T cells and NK cells was scarcely less frustrating. And the holy grail of ce- mediated cytotoxicity - defining the mechanism by which killer cells take down their adversaries - sorely tested the ingenuity, patience and mutual good will of laboratories around the world. These questions have now largely been answered. But do we really understand these cells? We can tame them to a large degree in transplant rejection. It may yet turn out that we can harness their immunotherapeutic potential in treating viral and malignant disease.
Place Published Dordrecht
Corporate Au Added Ent SpringerLink (Online service)
Host Item Entry Springer eBooks
PUB Date Free Form 2005
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20140717035135
Language eng
Origin SPRINGER
Type EBOOK
OCLC Rec Leader 03618nam a22005295i 45