||Initial Submission: TSCA Health and Safety Study Cover Sheet w/Continuation Sheet re: Results of Rat Pilot Teratology Study with CMC (Confidential), Benzimidazolyl Heterocycle, dated 12/22/1999. (Sanitized).
||FMC Corp., Princeton, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Body weight ;
Food consumption ;
Laboratory animals ;
Research and development ;
Benzimidazolyl heterocycle ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This study is being submitted due to the decreased fetal body weights seen at 5 mg/kg and greater and the increased early resorptions at 10 mg/kg and greater in the absence of maternal toxicity. Groups of eight mated female rats were adminstered (confidential) suspended in 1% carboxymethylcellulose (CMC) on days 6-19 of gestation. It is an experimental still in the R&D pre-commercialization phase. The dose levels were 0, 1.0, 3.0, 5.0, 10 and 30 mg/kg/day. Clinical observations were recorded daily; body weights and food consumption were recorded at three-day intervals. Prior to c-section, blood was collected for hematology determinations. A c-section was performed on each dam. Fetuses were weighed, sexed and examined for external alterations.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
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|PUB Date Free Form
||27 Dec 1999
||57Y; 57U; 68G; 99
||PC A02/MF A02