Main Title |
Development of the Linkage of Beta-Adrenergic Receptors to Cardiac Hypertrophy and Heart Rate Control: Neonatal Sympathectomy with 6-Hydroxydopamine. |
Author |
Hou, Q. C. ;
Seidler, F. J. ;
Slotkin, T. A. ;
|
CORP Author |
Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA-R-813769; EPA/600/J-89/379; |
Stock Number |
PB90-216201 |
Additional Subjects |
Hypertrophy ;
Heart diseases ;
Heart rate ;
Body weight ;
Nerve cells ;
Graphs(Charts) ;
Reprints ;
Hydroxydopamines ;
Adrenergic beta receptors ;
Chemical sympathectomy ;
Newborn animals ;
Organ weight ;
Isoproterenol
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-216201 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Presynaptic neural projections are thought to participate in the maturation of postsynaptic sensitivity to neurotransmitters. In the current study, the effects of sympathectomy with 6-hydroxydopamine on the ontogeny of the linkage of beta-adrenergic receptors to cardiac growth and heart rate control in the rat have been examined. Destruction of sympathetic projections at birth compromised the ability of beta-receptor stimulation to evoke cardiac hypertrophy, a defect which persisted into young adulthood. The chronotropic response to beta-receptor activation, assessed by acute challenge with a submaximally-effective dose of isoproterenol, also exhibited a slowed development, but did eventually achieve normal sensitivity. In contrast, neonatal sympathectomy had only minor effects on resting heart rate, basal heart rate (the intrinsic rate in the absence of autonomic input) or maximal heart rate; these animals also showed beta-receptor desensitization of chronotropic action in response to chronic isoproterenol treatment. (Copyright (c) Oxford University Press 1989.) |
Supplementary Notes |
Pub. in Jnl. of Developmental Physiology, v11 p305-311 May 89. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Development of the Linkage of Beta-Adrenergic Receptors to Cardiac Hypertrophy and Heart Rate Control: Neonatal Sympathectomy with 6-Hydroxydopamine. |
Category Codes |
57S; 57B; 57X |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
018016157 |
Origin |
NTIS |
Type |
CAT |