Main Title |
Understanding toxicology : a biological approach / |
Author |
Mercurio, Steven D.,
|
Publisher |
Jones & Bartlett Learning, |
Year Published |
2017 |
OCLC Number |
905970294 |
ISBN |
9780763771164; 0763771163 |
Subjects |
Environmental toxicology ;
Toxicological Phenomena ;
Noxae--toxicity ;
Hazardous Substances--toxicity ;
Drug-Related Side Effects and Adverse Reactions ;
Biological Factors--toxicity ;
Environmental Exposure
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
RA1226.M47 2017 |
|
Research Triangle Park Library/RTP, NC |
10/12/2017 |
|
Collation |
xix, 952 pages : illustrations ; 26 cm |
Notes |
Includes bibliographical references and index. |
Contents Notes |
Part I : Introduction. Biological research in toxicology -- Development of the field of toxicology -- Toxicology terms and how they relate to organisms -- Hazard, exposure, and risk modeling -- Part II : Toxic reactions of cells. Absorption and transport of toxicants through membranes : toxic damage to membranes -- Receptor-mediated toxicities on the outside of cells -- Detoxication and activation by cells : metabolism of the original toxicant -- Damage to cytosolic and endoplasmic reticulum activities -- Damage to mitochondrial and chloroplast activities -- Damage to nuclear structures/ DNA : mutagenesis and carcinogenesis -- Selective genetic sensitivity of cells to toxicants -- Nutritional toxicity and sensitivity -- Part III : Toxic reactions of tissues / organs. Routes of administration and which organs are most likely impacted based on route and toxicokinetic models -- Forensic toxicity testing -- The skin and eye : most likely exposure routes and toxicities due to contact exposure and dose toxicities -- Gastrointestinal system toxicity and oral exposure (GI tract, pancreas, liver) -- The lung and gill exposures representing toxic concentrations -- model for environmental toxicology -- The cardiovascular system as conduit for a dose becoming a dosage : exposure and toxicities -- Bone marrow and immune organ toxicity via lymphatic and blood transport -- The nervous system and exposure to lipophilic toxicants or transported neurotoxic agents -- Toxicity to neuroendocrine organs and endocrine disruption -- Toxicity to reproductive organs and developmental toxicity -- Excretion of hydrophilic toxicants and metabolites and kidney toxicity -- Part IV : Toxic reactions of ecosystems. Dispersion modeling in air, water, and soil : likely route of exposure and most sensitive organism based on dispersion and concentration -- Agricultural chemicals (pesticides and fertilizers) : exposure and impacts -- Industrial chemicals that biodegrade : organic chemical exposures and impacts -- Industrial chemicals that change lipophilicity but do not biodegrade : metal impacts -- Industrial chemicals that cause atmospheric changes and direct versus indirect toxicity : gases, vapors, aerosols, and radiation -- Toxicity of pharmaceuticals and personal care products (PPCPs) into water -- Part V : Biological toxicants. Venoms and injection toxicity versus poisonous animals or cells and ingestion or contact toxicity -- Poisonous plants or plant cells and ingestion or contact toxicity. |
Place Published |
Burlington, Massachusetts |
PUB Date Free Form |
©2017 |
BIB Level |
m |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
RDA |
LCCN |
2015011989 |
Merged OCLC records |
875644347 |
OCLC Time Stamp |
20171004052329 |
Language |
eng |
Origin |
OCLC |
Type |
CAT |
OCLC Rec Leader |
04157cam 2200481 i 45010 |