Main Title |
The U.S. Environmental Protection Agency's strategic plan for evaluating the toxicity of chemicals. |
Author |
M. Firestone ;
R. Kavlock ;
H. Zenick
|
CORP Author |
Environmental Protection Agency, Washington, DC. |
Publisher |
Office of the Science Advisor, Science Policy Council, U.S. Environmental Protection Agency, |
Year Published |
2009 |
Report Number |
EPA 100/K-09/001 |
Stock Number |
PB2010-112389 |
OCLC Number |
352789860 |
Subjects |
Chemicals--Research--United States ;
Toxicology ;
Toxicity testing--United States--Methodology ;
Hazardous Substances--toxicity ;
Environmental Exposure ;
Toxicity Tests--methods ;
United States Government Agencies ;
Toxicity testing--Methodology
|
Additional Subjects |
United States--Environmental Protection Agency--Rules and practice ;
Stragetic plans ;
Toxicity ;
Chemicals ;
Regulatory applications ;
Regulatory impacts ;
Toxicity pathways ;
Chemical screening ;
Risk assessments ;
Institutional transitions ;
Toxic substances ;
Hazardous materials ;
Toxicity pathway-based risk assessments
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
EPA 100/K-09/001 |
|
Region 1 Library/Boston,MA |
11/23/2009 |
EJBD |
EPA 100-K-09-001 |
|
Headquarters Library/Washington,DC |
03/21/2013 |
EKBD |
EPA-100/K-09-001 |
|
Research Triangle Park Library/RTP, NC |
06/02/2009 |
ELBD ARCHIVE |
EPA 100-K-09-001 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD RPS |
EPA 100 K-09-001 |
repository copy |
AWBERC Library/Cincinnati,OH |
05/21/2019 |
EMAD |
EPA 100/K-09/001 |
|
Region 6 Library/Dallas,TX |
09/30/2009 |
DISPERSAL |
ERAD |
EPA 100/K-09-001 |
|
Region 9 Library/San Francisco,CA |
01/28/2013 |
NTIS |
PB2010-112389 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
vii, 27 pages : illustrations (some color) ; 28 cm |
Abstract |
To fulfill its mission to protect human health and the environment, EPA must evaluate the risks of adverse health effects resulting from exposure to chemicals in the environment. The traditional risk assessment approach relies heavily on data generated through the intentional dosing of experimental animals. While this approach has provided EPA with sound science to support regulatory decision making over the past several decades, EPA must address ever-increasing demands, including consideration of complex issues such as cumulative exposures, life-stage vulnerabilities, and genetic susceptibilities, not to mention the increasing number of chemicals and cost of toxicity testing. A new approach is proposed to address these demands, an approach based on the application of advances in molecular biology and computational sciences to transform toxicity testing and risk assessment practices. EPA recently took the lead in commissioning the National Research Council (NRC) of the National Academies to develop a long-range vision for toxicity testing and risk assessment. Their 2007 report, Toxicity Testing in the 21st Century: a Vision and a Strategy, envisions a landmark transformation that focuses on identifying and evaluating 'toxicity pathways,' i.e., cellular response pathways responsible for adverse health effects when sufficiently perturbed by environmental agents under realistic exposure conditions. To build upon the transformative changes advocated in the NRC document, while ensuring an internally coordinated and integrated approach, EPA established a cross-Agency workgroup under the auspices of its internal Science Policy Council. This workgroup produced this report that provides a framework for EPA to comprehensively move forward to incorporate this new scientific paradigm into future toxicity testing and risk assessment practices. |
Notes |
"March 2009." "EPA 100/K-09/001." Includes bibliographical references. |
Place Published |
Washington, DC |
Availability Notes |
Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
Corporate Au Added Ent |
Science Policy Council (U.S.) |
PUB Date Free Form |
2009 |
Category Codes |
57Y; 99; 91A; 43F |
NTIS Prices |
PC A04 |
BIB Level |
m |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
OCLC/T |
LCCN |
2009416278 |
Control Number |
128600240 |
OCLC Time Stamp |
20190215063034 |
Language |
eng |
SUDOCS Number |
EP 1.2:T 66/22 |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
02506cam 2200637 a 45010 |