| Main Title |
Salmonella/mammalian-microsome Plate Incorporation Mutagenicity Assay (Ames Test) & a Chromosome Aberration Assay in Chinese Hamster Ovary Cells with Cover Letter Dated 04/15/1985. |
| CORP Author |
Microbiological Associates, Bethesda, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
40-8584197 |
| Stock Number |
OTS0525401 |
| Additional Subjects |
Toxicology ;
Health effects ;
9-octadecenylamine ;
Genotoxicity ;
Gene Mutations ;
Bacteria ;
In Vitro ;
Chromosomal Effects ;
Mammals ;
Hamsters ;
Toxic substances ;
Laboratory animals ;
CAS No 112-90-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525401 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
64p |
| Abstract |
9-Octadecenylamine (Z) (oleylamine) was assessed for mutagenicity in plate assays with Salmonella typhimurium strains TA1535, TA1537, TA1538, TA100, and TA98 in the presence and absence of Aroclor 1254-induced rat liver homogenate. Tests were conducted at 10 concentrations of test material, ranging from 10 to 10,000 ug/plate. Positive, negative, and solvent (acetone, 50 ug/plate) controls were also tested. No evidence of mutagenic activity was seen at any concentration of test material. A chromosomal aberration assay was conducted with Chinese hamster ovary cells exposed to concentrations of 0.05, 0.15, 0.5, or 1.5 nl/ml of test material in the absence of exogenous metabolic activation, and to concentrations of 0.6, 2, 6, or 20 nl/ml in the presence of Aroclor-induced rat liver homogenate. Under the conditions of these tests, oleylamine did not induce chromosome aberrations in Chinese hamster ovary cells. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802610 |
| Origin |
NTIS |
| Type |
CAT |
