Full Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Salmonella/mammalian-microsome Plate Incorporation Mutagenicity Assay (Ames Test) & a Chromosome Aberration Assay in Chinese Hamster Ovary Cells with Cover Letter Dated 04/15/1985.
CORP Author Microbiological Associates, Bethesda, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1985
Report Number 40-8584197
Stock Number OTS0525401
Additional Subjects Toxicology ; Health effects ; 9-octadecenylamine ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Chromosomal Effects ; Mammals ; Hamsters ; Toxic substances ; Laboratory animals ; CAS No 112-90-3
Library Call Number Additional Info Location Last
NTIS  OTS0525401 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 64p
Abstract 9-Octadecenylamine (Z) (oleylamine) was assessed for mutagenicity in plate assays with Salmonella typhimurium strains TA1535, TA1537, TA1538, TA100, and TA98 in the presence and absence of Aroclor 1254-induced rat liver homogenate. Tests were conducted at 10 concentrations of test material, ranging from 10 to 10,000 ug/plate. Positive, negative, and solvent (acetone, 50 ug/plate) controls were also tested. No evidence of mutagenic activity was seen at any concentration of test material. A chromosomal aberration assay was conducted with Chinese hamster ovary cells exposed to concentrations of 0.05, 0.15, 0.5, or 1.5 nl/ml of test material in the absence of exogenous metabolic activation, and to concentrations of 0.6, 2, 6, or 20 nl/ml in the presence of Aroclor-induced rat liver homogenate. Under the conditions of these tests, oleylamine did not induce chromosome aberrations in Chinese hamster ovary cells.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
PUB Date Free Form 1985
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A05/MF A05
Document Type NT
Cataloging Source NTIS/MT
Control Number 028802610
Origin NTIS
Type CAT