||Mutagenicity Evaluation of Tetrafluoroethylene in Cho/hprt Assay with Cover Letter dated 08/22/1986.
||Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Tetrafluoroethylene (116-14-3) ;
Gene Mutations ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 116-14-3
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The ability of tetrafluoroethylene to induce specific locus mutations at the HGPRT locus in cultured Chinese hamster ovary (CHO) cells (CHO/HGPRT Mutagenicity Assay) was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Based on preliminary toxicity determinations, tetrafluoroethylene, was tested at nominal concentrations of 0, 20, 40, 60, 80 and 100% for treatments with and without metabolic activation. Twenty two nonactivated cultures produced a range of 100.0 - 56.5% cell survival relative to the negative control and twenty two activated cultures produced a range of 133.4 - 49.3% relative cell survival. None of the cultures produced mutant frequencies significantly greater than the negative control with or without metabolic activation.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.
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||57Y; 57U; 68G; 99; 44G
||PC A03/MF A03