||Mouse Teratogen Dinocap Has Lower A/D Ratios and Is Not Teratogenic in the Rat and Hamster (Journal Version).
Rogers, J. M. ;
Barbee, B. ;
Burkhead, L. M. ;
Rushin, E. A. ;
Kavlock, R. J. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Environmental surveys ;
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The fungicide dinocap is currently used in the control of powdery mildew. The authors have reported that dinocap is teratogenic in the CD-1 mouse, causing cleft palate, otolith defects, and fetal weight deficits well below maternotoxic dose levels. In the study the maternal and fetal toxicity of dinocap was determined in the Sprague-Dawley rat and Syrian golden hamster, and Adult-to-Developmental (A/D) toxicity ratios were calculated and compared to the previously established A/D ratio of dinocap in the mouse. The A/D ratios for dinocap in the rat and hamster are similar, and are approximately one. These previous studies have demonstrated that dinocap is teratogenic in the mouse, with an A/D ratio in the range of 8-16 in the species. The basis for the species-specific teratogenicity and inconsistent A/D ratio of dinocap is unknown.
||Pub. in Teratology, v37 p553-559 1988.
|NTIS Title Notes
||57F; 57Y; 68E
||PC A02/MF A01