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OLS Field Name OLS Field Data
Main Title Metabolism of alpha-Naphthoflavone by Rat, Mouse, Rabbit, and Hamster Liver Microsomes.
Author Bergman, H. B. ; Bryant, B. J. ; Nesnow, S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-600/J-84-034;
Stock Number PB84-206150
Additional Subjects Ribosomes ; Rats ; Mice ; Rabbits ; Hamsters ; Reprints ; Metabolites ; Naphthoflavone
Holdings
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NTIS  PB84-206150 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Abstract The metabolism of alpha-naphthoflavone (ANF) was studied in hepatic microsomes from rats, mice, rabbits, and hamsters, species in which ANF exerts its biological activities. The major metabolites produced by all species were ANF-5,6-oxide, ANF-6-phenol, and ANF-7,8-dihydrodiol. Minor metabolites produced by all species were ANF-5,6-dihydrodiol, ANF-7-phenol, and ANF-9-phenol. In general, the total rates of metabolism were similar within all species: 22-32 nmol ANF metabolized/15 min/mg protein. Mouse liver microsomes were approximately 1.7 to 2.9 times as active as the other species on a nanomole P-450 basis. The major sites of enzymatic oxidation were the 5,6 and 7,8 bonds of ANF where for all species, 94-71% and 15-46% of the total metabolism occurred, respectively.
Availability Notes Pub. in Toxicology and Applied Pharmacology, 72 p469-475 1984.
NTIS Title Notes Journal article.
Title Annotations Reprint: Metabolism of alpha-Naphthoflavone by Rat, Mouse, Rabbit, and Hamster Liver Microsomes.
PUB Date Free Form c1984
Category Codes 6T; 6O; 57Y; 57Q
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 424418696
Origin NTIS
Type CAT