Main Title |
Cho/hgprt Test on Cumene with Cover Letter. |
CORP Author |
Gulf Oil Exploration and Production Co., Oklahoma City, OK.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1985 |
Report Number |
878216011 |
Stock Number |
OTS0206775 |
Additional Subjects |
Toxicology ;
Health effects ;
Cumene (98-82-8) ;
Genotoxicity ;
Gene Mutations ;
Mammals ;
Hamsters ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 98-82-8
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0206775 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
29p |
Abstract |
The ability of cumene to induce mutations at the gene locus coding for hypoxanthine-guanine phosphoribosyl transferase in Chinese hamster ovary cells (CHO/HGPRT Assay) was evaluated in the presence and absence of metabolic activation from Aroclor-induced rat liver S9 fraction. Based on preliminary cytotoxicity tests, nonactivated cultures were treated with cumene at concentrations of 8, 16, 32, 64, and 128 mcg/ml producing cell survivals relative to the vehicle control (Pluronic F127) of 122.9, 92.8, 104.7, 124.6, and 89.2% respectively. Activated cultures treated with cumene concentrations of 64, 128, 150, and 175 mcg/ml produced relative cell survivals ranging from 91.0 - 7.6%. A significant mutagenic response was not observed in either activated or nonactivated trials. |
Supplementary Notes |
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Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
1985 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801060 |
Origin |
NTIS |
Type |
CAT |