Main Title |
In Vitro Chromosome Aberration Assay with Isobutyraldehyde in V79 Cells, with Cover Letter dated 08/03/1999. |
CORP Author |
BASF Corp., Mount Olive, NJ.; BASF A.G., Ludwigshafen am Rhein (Germany, F.R.). Aktiengesellschaft labor fuer Umweltanalytik und Okologie.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1999 |
Stock Number |
OTS0573896 |
Additional Subjects |
Toxicology ;
Health effects ;
Isobutyraldehyde ;
Genotoxicity ;
Chromosomal effects ;
Mammals ;
Hamsters ;
In vitro ;
CAS No 78-84-2
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0573896 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
79p |
Abstract |
The aim of the present study was to assess the potential of the test substance isobutyraldehyde or its metabolite(s) to induce structural chromosomal aberrations. For this purpose, an in vitro cytogenetic assay was carried out to determine chromosome aberration frequencies in V79 cells. Most of the substances are not mutagenic or carcinogenic themselves, but only after metabolic transformation, which in vivo is catalyzed mainly by the enzyme systems of the liver. Therefore, the tests are carried out not only directly, but also in the presence of an exogenous metabolic activation system. The most commonly used system is a cofactor- supplemented postmitochondrial fraction (S-9) obtained from livers of rats treated with an enzyme-inducing agent, e.g. Aroclor 1254. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
9 Aug 1999 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A06/MF A06 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028701980 |
Origin |
NTIS |
Type |
CAT |