| Main Title |
Toxicity and Health Hazard Summary with Cover Letter. Formamide. |
| CORP Author |
Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
878214410 |
| Stock Number |
OTS-0206566 |
| Additional Subjects |
Toxicity ;
Oral doses ;
Lethal doses ;
Rats ;
Laboratory animals ;
Guinea pigs ;
Skin irritation ;
Skin sensitization ;
Toxic substances ;
Hazardous materials ;
Formamide ;
Methanamide ;
CAS No 75-12-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0206566 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
By the acute oral route, formamide is practically non-toxic having an LD50 of 7.5 gm/kg in rats. When the compound was held in occluded contact with the skin of guinea pigs for 24 hours, it caused slight skin irritation. However, animals receiving 5 and more cc/kg died in 2 to 6 days. The animal receiving a dose of 1 cc/kg survived. Rabbits seen less susceptible to intoxication by the cutaneous routes; an LD50 of 17 gm/kg has been recorded for the species. In a standard test for skin sensitization in guinea pigs, 0/5 animals were sensitized. Rats exposed to atmospheric concentrations as high as 54 mg/L of the material evaporated from a 50% mixture of fornamide and methanol failed to demonstrate any signs for a period of six hours, and the weight gain in the subsequent two-veek observation period was essentially normal for animals of this size. Because of the differential in boiling points of methanol and formanide, it seems apparent that the vast majority of the material vaporized into the exposure chamber would have been methanol, and only a small portion of the exposure could be attributed to the formanide. When the undiluted compound was placed in the eye of a rabbit, it produced a mild, presumably reversible injury that was graded 4 on a scale of 1 to 10. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
5 Apr 1984 |
| Category Codes |
57Y |
| NTIS Prices |
PC A01/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019000340 |
| Origin |
NTIS |
| Type |
CAT |
