Main Title |
Initial Submission: Nine-Day Repeated Vapor Inhalation Toxicity Study of Butyraldehyde with Cover Letter dated 10/10/1992. |
CORP Author |
Carnegie-Mellon Inst. of Research, Pittsburgh, PA.; Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1992 |
Report Number |
8EHQ-1092-11380 |
Stock Number |
OTS0571318 |
Additional Subjects |
Toxicology ;
Health effects ;
Butyraldehyde ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
Mice ;
Guinea pigs ;
Rabbits ;
Dogs ;
CAS No 123-72-8
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0571318 |
Some EPA libraries have a fiche copy filed under the call number shown. |
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07/26/2022 |
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Collation |
32p |
Abstract |
Rats, mice, guinea pigs, rabbits and dogs were exposed to butyraldebyde vapor 6 hours/day, 5 days/week for 9 days over a two-week period. The measured concentrations for the 3 test levels were 6400, 3100 and 2000 ppm. Definite signs of eye and respiratory irritation, and statistically significantly lower body weight findings were observed in most species inhaling 6400 and 3100 ppm of butyraldehyde. Other signs observed in most animals at 6400 ppm included coordination loss, anesthesia and death. At 3100 ppm these effects were observed only in the beagle dog. Only some eye and respiratory irritation and statistically significantly lower body veight effects were observed among animals inhaling 2000 ppm of buryraldehyde. Scattered organ weight effects were found in rats for both test groups (3100 and 2000 ppm) surviving the 9-day inhalation treatment. (Further interpretation of these organ weight findings will probably be forthcoming in the following 13 week study.) No pathologically significant treatment related gross lesions were found among animals inhaling 3100 or 2000 ppm of butyraldehyde. One male Sprague-Dawley rat that had been exposed to 6400 ppm had bilateral hemorrhage of the ethmoturbinates. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
27 Oct 1992 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A04/MF A04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
018802230 |
Origin |
NTIS |
Type |
CAT |