| Main Title |
Initial Submission: Skin Sensitization Test in Guinea Pigs (Maximization Method of Magnusson, B. and Kligman, A.M.) of Dibenzyl Disulfide, with Cover Letter dated 12/18/1995. |
| CORP Author |
Elf Atochem North America, Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1996 |
| Report Number |
8EHQ-0196-13572 |
| Stock Number |
OTS0558446 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Dibenzyl disulfide ;
Laboratory animals ;
Primary dermal sensitization ;
Mammals ;
Guinea pigs ;
Dermal ;
CAS No 150-60-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558446 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
34p |
| Abstract |
Thirty guinea-pigs were allocated to two groups: a control group 1 (five males and five females) and a treated group 2 (ten males and ten females). On day 1, in the dorsal region between the shoulders, intradermal injections of Freund's complete adjuvant mixed with the test substance (treated group) or the vehicle (control group) were prepared. On day 7, the same region received a topical application of sodium laurylsulfate in vaseline (10% w/w) in order to induce local irritation. On day 8, this same test site was treated by topical application of the test substance (treated group) or the vehicle (control group) and was covered by an occlusive dressing for 48 hours. Test substance and vehicle were maintained under an occlusive dressing for 24 hours. Skin reactions were evaluated approximately 24 and 48 hours later. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
15 Jan 1996 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501200 |
| Origin |
NTIS |
| Type |
CAT |
