| Main Title |
Initial Submission: Letter to USEPA Reporting Results of Guinea Pig Maximization Test on (Confidential Information), dated 12/02/99 (Sanitized). |
| CORP Author |
;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
6 Dec 1999 |
| Year Published |
1999 |
| Report Number |
8EHQ-1199-14603S; |
| Stock Number |
OTS-0559850 |
| Additional Subjects |
Toxicity ;
Erythema ;
Guinea pigs ;
Laboratory animals ;
Concentration ;
Skin sensitization ;
Edema ;
Dermal irritation responses ;
Lubricant additive components ;
Guinea Pig Maximization Test
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0559850 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The skin sensitization potential of the test material was evaluated in the Guinea Pig Maximization Test. At 48 hours following challenge application of the undiluted test material, 60% of the treated animals exhibited a positive reaction ranging from moderate to severe erythema. Edema was also noted in four out of twenty treated animals during the post-challenge observation. For the rechallenge, the test material was diluted to 50 wt% in olive oil to reduce the dermal irritation responses noted during challenge. At 48 hours post- rechallenge, 30% of the treated animals exhibited a positive reaction ranging from slight to moderate erythema. Based on the conditions of this test and the results of the challenge and rechallenge, the test material displayed moderate skin sensitization potential. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102040 |
| Origin |
NTIS |
| Type |
CAT |
