Main Title |
Chlorambucil Induced Congenital Renal Hypoplasia: Effects on Basal Renal Function in the Developing Rat. |
Author |
Kavlock, R. J. ;
Rehnberg, B. F. ;
Rogers, E. H. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/213; |
Stock Number |
PB87-169611 |
Additional Subjects |
Toxicity ;
Rat ;
Growth abnormalities ;
Kidney ;
Urologic diseases ;
Reprints ;
Renal hypoplasia ;
Chlorambucil ;
Teratology ;
Renal function
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-169611 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
Administration of chlorambucil to pregnant rats on day 11 of gestation induced dose-related alterations in renal growth and function in the postnatal offspring. These effects occurred above and beyond the reductions in body growth and were evident in animals that displayed no overt malformation of the urogenital tract. Reductions in overall growth amounted to 0,6 and 15% in the 3,4.5 and 6 mg/kg groups, respectively, while kidney weights were reduced by 7, 15 and 23%. The weights of the kidneys relative to the body were reduced 5,9 and 10% with increasing dose. Although basal renal function was not affected by the degree of hypoplasia seen in the low dose group, reduced glomerular and tubular function were evident following a basal clearance test in the 2 highest dose groups. The data indicate that chlorambucil induced renal hyopolasia results in reductions in renal function that persist for at least the first 3 weeks after birth in the rat and that physiological assessment of development toxicity can provide an extremely useful addendum to the more classical morphological criteria. |
Supplementary Notes |
Pub. in Toxicology 40, p247-258 1986. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Chlorambucil Induced Congenital Renal Hypoplasia: Effects on Basal Renal Function in the Developing Rat. |
PUB Date Free Form |
1986 |
Category Codes |
68G; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
715627328 |
Origin |
NTIS |
Type |
CAT |