| Main Title |
Two-Generation Reproductive Toxicity Evaluation of Butyl Benzyl Phthalate Administered in the Feed to CD(R) (Sprague-Dawley) Rats. |
| Author |
Tyl, R. W. ;
Myers, C. B. ;
Marr, M. C. ;
|
| CORP Author |
Ferro Corp., Cleveland, OH. ;Research Triangle Inst., Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
31 Jan 2002 |
| Year Published |
2002 |
| Report Number |
OTS-89020000082 ;8EHQ-0302-14864; |
| Stock Number |
OTS-0574132-2 |
| Additional Subjects |
Rats ;
Reproduction ;
Toxicity ;
Health effects ;
Weight ;
Food consumption ;
Cytology ;
Fertility ;
Lactation ;
Growth ;
Development ;
Sprague-Dawley rats ;
Benzyl phthalate
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0574132-2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1092p |
| Abstract |
The purpose of this study was to evaluate the potential of butyl benzyl phthalate (BBP), administered in the feed to CD(trademark) rats, to produce alterations in parental fertility, maternal pregnancy and lactation, and growth and development of the offspring for two generations, one litter per generation. This study was performed in compliance with U.S. EPA Toxic Substances Control Act (TSCA), Good Laboratory Practice Standards (U.S. EPA, 1989), and the U.S. EPA OPPTS Testing Guidelines (U.S. EPA, 1998). Male and female CD(trademark) (Sprague-Dawley) rats (the F0 generation) were administered BBP (1, 2-Benzenedicarboxylic acid, butyl phenylmethyl ester (9CI); CAS No. 85-68-7) in the feed at 0, 750, 3750, and 11,250 ppm, available ad libitum, 30 animals/sex/dose, for ten weeks. Body weights and feed consumption were recorded weekly, and clinical signs were recorded at least once daily. Vaginal cytology was evaluated for the last three weeks of the prebreed period. Animals were then randomly mated within treatment groups for a two-week mating period to produce the F1 generation, with exposure continuing. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Research Triangle Inst., Research Triangle Park, NC. |
| Availability Notes |
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| Category Codes |
57E; 57Y |
| NTIS Prices |
PC A99/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
005100310 |
| Origin |
NTIS |
| Type |
CAT |
