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RECORD NUMBER: 446 OF 879

OLS Field Name OLS Field Data
Main Title Interspecies Modeling of Inhaled Particle Deposition Patterns.
Author Martonen, T. B. ; Zhang, Z. ; Yang, Y. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Rhode Island Univ., Kingston. Dept. of Mechanical Engineering. ;North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/124;
Stock Number PB93-181121
Additional Subjects Species diversity ; Particles ; Air pollution effects(Humans) ; Pharmacokinetics ; Rats ; Humans ; Lung ; Carbon dioxide ; Graphs(Charts) ; Reprints ;
Holdings
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Status
NTIS  PB93-181121 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/23/1993
Collation 15p
Abstract To evaluate the potential toxic effects of ambient contaminants or therapeutic effects of airborne drugs, inhalation exposure experiments can be performed with surrogate laboratory animals. Herein, an interspecies particle deposition theory is presented for physiologically based pharmacokinetic modeling. It is derived to improve animal testing protocols. The computer code describes the behavior and fate of particles in the lungs of human subjects and a selected surrogate, the laboratory rat. In the simulations CO2 is integrated with exposure chamber atmospheres, and its concentrations regulated to produce rat breathing profiles corresponding to selected levels of human physical activity. The dosimetric model is used to calculate total, compartmental (i.e., tracheobronchial and pulmonary), and localized distribution patterns of inhaled particles in rats and humans for comparable ventilatory conditions. It is demonstrated that the model can be used to predetermine the exposure conditions necessary to produce deposition patterns in rats that are equivalent to those in humans at prescribed physical activities.
Supplementary Notes Pub. in Jnl. of Aerosol Science, v23 n4 p389-406 Jul 92. See also PB93-181105. Prepared in cooperation with Rhode Island Univ., Kingston. Dept. of Mechanical Engineering, and North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.
NTIS Title Notes Journal article.
Title Annotations Reprint: Interspecies Modeling of Inhaled Particle Deposition Patterns.
Category Codes 68A; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 317523685
Origin NTIS
Type CAT