||Interspecies Modeling of Inhaled Particle Deposition Patterns.
Martonen, T. B. ;
Zhang, Z. ;
Yang, Y. ;
||Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Rhode Island Univ., Kingston. Dept. of Mechanical Engineering. ;North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.
Species diversity ;
Air pollution effects(Humans) ;
Carbon dioxide ;
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||To evaluate the potential toxic effects of ambient contaminants or therapeutic effects of airborne drugs, inhalation exposure experiments can be performed with surrogate laboratory animals. Herein, an interspecies particle deposition theory is presented for physiologically based pharmacokinetic modeling. It is derived to improve animal testing protocols. The computer code describes the behavior and fate of particles in the lungs of human subjects and a selected surrogate, the laboratory rat. In the simulations CO2 is integrated with exposure chamber atmospheres, and its concentrations regulated to produce rat breathing profiles corresponding to selected levels of human physical activity. The dosimetric model is used to calculate total, compartmental (i.e., tracheobronchial and pulmonary), and localized distribution patterns of inhaled particles in rats and humans for comparable ventilatory conditions. It is demonstrated that the model can be used to predetermine the exposure conditions necessary to produce deposition patterns in rats that are equivalent to those in humans at prescribed physical activities.
||Pub. in Jnl. of Aerosol Science, v23 n4 p389-406 Jul 92. See also PB93-181105. Prepared in cooperation with Rhode Island Univ., Kingston. Dept. of Mechanical Engineering, and North Carolina Univ. at Chapel Hill. Center for Environmental Medicine and Lung Biology.
|NTIS Title Notes
||Reprint: Interspecies Modeling of Inhaled Particle Deposition Patterns.
||PC A03/MF A01