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RECORD NUMBER: 244 OF 882

OLS Field Name OLS Field Data
Main Title Differential Impact of Hypothermia and Pentobarbital on Brain-Stem Auditory Evoked Responses.
Author Janssen, R. ; Hetzler, B. E. ; Creason, J. P. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Lawrence Univ., Appleton, WI.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/262;
Stock Number PB92-113240
Additional Subjects Hypothermia ; Pentobarbital ; Auditory brain stem evoked potentials ; Anesthesia ; Body temperature regulation ; Graphs(Charts) ; Comparison ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-113240 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/24/1992
Collation 12p
Abstract Two experiments were conducted to determine the effects of hypothermia and pentobarbital anesthesia, alone and in combination, on the brain-stem auditory evoked responses (BAERs) of rats. In experiment I, unanesthetized rats were cooled to colonic temperatures 0.5 and 1.0 C below normal. In experiment II, 2 groups of rats were cooled and tested at 37.5, 36.0, 34.5 and 31.5 C. One group was anesthetized during testing and the other group was awake. The rat BAER was sensitive to cooling of 1 C or less. Peak latencies were prolonged and peak-to-peak amplitudes were increased by hypothermia alone. The effect on amplitude may be related to the time course of temperature change or to stimulus level. Pentobarbital significantly affected both latencies and amplitudes over and above the effects of cooling. The specific effects of pentobarbital differed by BAER peak and by temperature. The findings point up the importance of the potential confound of anesthetic drugs in most of the evoked potential literature on hypothermia and, for the first time, quantify the complex interactions between pentobarbital and temperature which affect the BAER wave form. (Copyright (c) 1991 Elsevier Scientific Publishers Ireland, Ltd.)
Supplementary Notes Pub. in Electroencephalography and Clinical Neurophysiology, v80 n5 p412-421 Sep 91. Prepared in cooperation with Lawrence Univ., Appleton, WI.
NTIS Title Notes Journal article.
Title Annotations Reprint: Differential Impact of Hypothermia and Pentobarbital on Brain-Stem Auditory Evoked Responses.
Category Codes 57Q; 57W; 57I
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 201026503
Origin NTIS
Type CAT