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OLS Field Name OLS Field Data
Main Title Metabolism of carbamate insecticides /
Author Dorough, H. W.
CORP Author Kentucky Univ., Lexington. Dept. of Entomology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher Environmental Sciences Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1977
Report Number EPA-600/1-77-012; EPA-R-802005
Stock Number PB 266 223
OCLC Number 52399418
Subjects Carbamates. ; Pesticides.
Additional Subjects Insecticides ; Pesticides ; Carbamates ; Esters ; Metabolism ; Hydrolysis ; Laboratory animals ; Domestic animals ; Plants(Botany) ; Food chains ; Toxicology ; Carcinogens ; In vitro analysis ; In vivo analysis ; Biochemistry ; Physiology ; Glutathione ; Metabolites ; Pesticide residues ; Mutagens ; Ames mutagenic assay system
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-77-012 Headquarters Library/Washington,DC 11/28/2011
EJBD  EPA 600-1-77-012 Headquarters Library/Washington,DC 01/17/2014
EKBD  EPA-600/1-77-012 Research Triangle Park Library/RTP, NC 06/20/2003
ELBD  EPA 600-1-77-012 AWBERC Library/Cincinnati,OH 12/26/2017
ERAD  EPA 600/1-77-012 Region 9 Library/San Francisco,CA 06/11/2012
NTIS  PB-266 223 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 244 pages : illustrations ; 28 cm.
Abstract The results of studies conducted to determine the metabolic fate of carbamate insecticides and its toxicological significance are presented. Methomyl metabolism in rats was investigated in detail as was Croneton in the rat, cow, pig and chicken. Carbaryl and carbofuran were administered to rats endotracheally either as aerosols or as components of tobacco smoke and their fate determined. Carbaryl and nitrosocarbaryl were among a series of pesticides assayed for mutagenic/carcinogenic activity using the Ames assay system. In addition, a study was conducted to determine if the in vitro metabolism of carbaryl under conditions of the Ames assay was representative of that which occurs in vivo. Respiratory 14C-carbon dioxide from carbonyl-labeled carbamates was evaluated as a technique for determining the effects of various factors on the metabolism of carbamate insecticides. Carbaryl and certain of its analogs were used in studies designed to define the role of glutathione conjugation in carbamate metabolism in rats. Conjugate and bound residues of carbaryl, carbofuran, Croneton and aldicarb formed by plants were administered orally to rats and their bioavailability ascertained.
Notes EPA-600/1-77-012. "February 1977." Includes bibliographical references (pages 226-235).
Place Published Research Triangle Park, NC
Supplementary Notes See also PB-231 596.
Corporate Au Added Ent United States. Environmental Protection Agency. Office of Research and Development.; Environmental Sciences Research Laboratory.
Title Ser Add Ent Ecological health effects research series.
PUB Date Free Form 1977
Series Title Traced Ecological health effects research series
Series Title Untraced Ecological health effects research series
NTIS Prices PC A12/MF A01
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
OCLC Time Stamp 20171222060500
Language eng
SUDOCS Number EP 1.23/4:600/1-77-012
Origin OCLC
OCLC Rec Leader 01783cam 2200469Ka 45010